In-Depth Characterization of Live Vaccines Used in Europe for Oral Rabies Vaccination of Wildlife
نویسندگان
چکیده
Although rabies incidence has fallen sharply over the past decades in Europe, the disease is still present in Eastern Europe. Oral rabies immunization of wild animal rabies has been shown to be the most effective method for the control and elimination of rabies. All rabies vaccines used in Europe are modified live virus vaccines based on the Street Alabama Dufferin (SAD) strain isolated from a naturally-infected dog in 1935. Because of the potential safety risk of a live virus which could revert to virulence, the genetic composition of three commercial attenuated live rabies vaccines was investigated in two independent laboratories using next genome sequencing. This study is the first one reporting on the diversity of variants in oral rabies vaccines as well as the presence of a mix of at least two different variants in all tested batches. The results demonstrate the need for vaccine producers to use new robust methodologies in the context of their routine vaccine quality controls prior to market release.
منابع مشابه
Oral Vaccination Campaigns of Dogs against Rabies
Effective control of terrestrial wildlife rabies seemed almost impossible in Europe until the development of oral vaccination. Nowadays, oral vaccination of foxes (Vulpes vulpes) by distributing vaccine baits is the method of choice in rabies control in most European countries. Consequently, large areas are now rabies-free and here baits are no longer distributed or the distribution of baits is...
متن کاملSpatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe
In Europe, the elimination of wildlife rabies using oral rabies vaccination [ORV] of foxes for more than 30 years has been a success story. Since a comprehensive review on the scope of the different oral rabies vaccine baits distributed across Europe has not been available yet, we evaluated the use of different vaccine baits over the entire period of ORV [1978-2014]. Our findings provide valuab...
متن کاملThe Role of the Gray Wolf in Rabies Transmission in Iran and Preliminary Assessment of an Oral Rabies Vaccine in this Animal
Introduction: In Iran, 95% of animal bites are attributed to domestic dogs and cats, while one-third of rabies victims are from wildlife. The wolf is one of the primary vectors of wildlife in the country. This study was aimed to assess the impact of wildlife on rabies transmission and to evaluate the efficacy of an oral rabies vaccine (ORV) in the gray wolf (Canis lupus pallipes). Methods: We s...
متن کاملAdverse reactions from consumption of oral rabies vaccine baits in dogs in Finland
BACKGROUND Oral rabies vaccination of wildlife has effectively reduced the incidence of rabies in wildlife and has led to the elimination of rabies in large areas of Europe. The safety of oral rabies vaccines has been assessed in both target (red fox and raccoon dog) and several non-target species. CASE PRESENTATION Since 2011, the competent authority in Finland has received a few reports of ...
متن کاملThe Oral Delivery of Rabies Vaccines to Dogs
In most developing countries the dog remains the major transmission vector of rabies to man, despite the widespread use of parenteral vaccination. Parenteral vaccination does not, in general, achieve population immunity levels high enough to inhibit rabies transmission within the dog population. Following the demonstration that oral vaccination induced levels of population immunity sufficient t...
متن کامل